Deep sleep isn’t just rest—it’s when the glymphatic system flushes metabolic waste from the brain, including beta-amyloid, more efficiently than during wakefulness [1]. In parallel, autophagy—the cell’s recycling program—runs on a circadian timer and ramps with fasting cues, supporting mitochondrial cleanup and proteostasis overnight [2]. DeepCell is designed to work with these nocturnal processes.

A calm nervous system → faster sleep onset and deeper stages.

Magnesium glycinate improved sleep indices in a randomized, double-blind trial of adults with poor sleep [3].

L-theanine increased relaxation biomarkers and supports sleep quality in controlled human studies [4].

Lemon balm (Melissa officinalis) reduced anxiety and improved sleep measures in a randomized, placebo-controlled trial [5].

Together, these actives promote balanced NREM/REM architecture without sedation.

We support the pathway—not replace the hormone. L-tryptophan is the dietary precursor to serotonin → melatonin, with vitamin B6 as a required cofactor in the conversion steps [6]. Zinc participates in enzymes governing melatonin synthesis and has been linked to better sleep quality in human data [7].

DeepCell’s polyphenol stack targets longevity signaling linked to autophagy and AMPK:

EGCG (green tea catechin) modulates AMPK/mTOR and has been shown to trigger autophagy in preclinical models [9]. A 12-month randomized study of matcha (EGCG-rich) in older adults reported sleep-quality improvements alongside cognitive measures [10].

Apigenin (the chamomile flavonoid) interacts with GABA_A receptors and shows sedative effects in animals, with emerging links to healthy aging mechanisms [11].

These are supportive, non-sedating routes to overnight cellular upkeep.

Our Lithium Orotate 50 mg capsule yields ~2 mg elemental Li, a trace amount. Preclinical work (Nature, 2025) found that low-dose lithium orotate avoided plaque binding and reversed Alzheimer-like pathology and memory deficits in mice; human trials are the next step [12]. Ecological and translational reviews also associate low-dose lithium exposure with neuroprotective signals across cognition and mood [13].

No sedatives. No tolerance spiral. We intentionally exclude high-dose melatonin and hypnotics that can impair next-day function or disrupt architecture. AASM guidance places behavioral and non-sedative strategies first line and does not recommend melatonin for chronic insomnia in adults [8]. DeepCell’s stack is GMP-manufactured, third-party tested, and formulated for nightly sustainability—so you wake clear, not groggy.

References

[1] Xie et al. Science (2013): Sleep markedly increases glymphatic clearance of brain metabolites. PubMed

[2] Wang et al. Frontiers in Cell & Dev Bio (2020): Circadian control of autophagy and its metabolic roles. Frontiers

[3] Schuster et al. (2025) RCT: Magnesium bisglycinate improved sleep quality in adults with poor sleep. PMC

[4] Evans et al. Nutrients (2021) RCT (L-theanine) + 2025 systematic review of L-theanine for sleep. PMC+1

[5] Bano et al. Front Pharmacol (2023): Melissa officinalis reduced distress and improved sleep vs. placebo. PubMed

[6] Kautz et al. (2024) review: Tryptophan→serotonin→melatonin pathway; B6 as cofactor. PMC

[7] Zinc–sleep evidence: mechanistic and human data review. MDPI

[8] AASM Clinical Practice Guideline (2017): Suggest not using melatonin for chronic insomnia in adults. AASM

[9] Rahman et al. (2024) review: EGCG modulates AMPK/mTOR and autophagy; additional mechanistic support. PMC

[10] Uchida et al. PLOS ONE (2024) RCT: 12-month matcha intake improved sleep quality in older adults. PLOS

[11] Srivastava et al. (2010) review; Kramer et al. (2024) review: Apigenin binds GABA_A sites; sedative effects in animals. PMC+1

[12] Nature paper + news (2025): Lithium orotate reversed AD-like pathology and memory deficits in mice; reduced plaque binding. Nature+1

[13] Fraiha-Pegado et al. (2024) review: Trace lithium exposure and dementia risk; broader low-dose neuroprotection literature. PMC

*Disclaimer
“These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”